摘要
眼表黏蛋白MUC5AC是由结膜杯状细胞分泌的大分子胶样分泌性黏蛋白,其溶解于泪膜的水液层,具有清理眼表碎屑、防止眼表结构受到伤害、润滑眼表、促进泪液排出、维持泪膜稳定、防止病原体侵入、对眼表止血等作用.MUC5AC黏蛋白与许多眼表疾病有密切关系.感染性疾病、免疫性疾病、准分子激光手术、配戴角膜接触镜及维生素缺乏等均可引起MUC5AC表达水平的下降或反应性升高,引起多种临床症状,并使眼表抵御外界侵袭的能力下降,发生干眼、眼表过敏性疾病、变性类疾病等.
Mucin5AC in ocular surface is a macromolecule gel-forming secretory mucin expressed by conjunctival goblet cells,and dissolved in aqueous tear film layer.MUC5AC has many functions such as clearing fragments that exist in ocular surface,keeping ocular surface from harm,lubricating,promoting the tear drainage,keeping the stability of the tear film,preventing the invasive pathogens and stopping bleeding,et al.MUC5AC related with many ocular diseases.The expression of MUC5AC can be affected by many conditions,such as infectious and immunologic diseases,LASIK,corneal contact lens wearing,and vitamin deficiency,which may lead to clinical symptoms,or reduce the ability of resisting the invade and attack from outside.Thus,diseases like dry eye,allergic disease,and degenerative disease may occure.
出处
《国际眼科纵览》
2014年第3期160-164,共5页
International Review of Ophthalmology
