挤压伤——挤压综合征的实验病理学研究

An experiment pathologic study of crush injury—crush syndrome

观察挤压伤后挤压综合征的发生发展过程及肾脏病理改变特点。以家兔制造挤压伤—挤压综合征的动物模型 ,取血和尿进行生化检验并应用光镜、电镜及免疫组化等方法 ,观察肾脏的形态学改变。结果显示 :(1)挤压伤后血K+和血BUN明显升高 ,血CO2 CP明显下降 (P <0 0 5 ) ;(2 )在挤压综合征时 ,肾脏肾小球肿胀 ,肾小管上皮细胞不同程度的变性坏死 ,管腔内有以肌红蛋白为主要成分的管型 ,血BUN持续下降 ,血K+改变不明显。肾小管上皮细胞的变性坏死及肾小管内肌红蛋白管型形成可作为挤压综合征的法医病理学诊断依据之一 。

To study the pathological process and renal patho morphology of crush syndromed.The rabbit model of crush injury crush syndrome was established.Transmission electron microscopy(TEM),biochemistry,radioimmunoassay and immuohistochemistry were employed.The results demonstrated that the serum K + and BUN increased,The serum CO 2CP decreased after crush injury.The degeneration and necrosis of the epithelial cells of the renal tubule and myoglobin casts in the renal tubules were observed in crush syndrome,the serum K + increase was absent.Our results may be regarded as criteria for the diagnosis of the crush injury crush syndrome.The serum K + increase was the cause of death in early stage after crush injury.