X综合征冠状循环内血浆内皮素浓度变化

Changes of plasma endothelin levels in coronary circulation in patients with syndrome X

目的 探讨X综合征患者中冠状血管内皮功能的变化。方法 采用心房起搏术 ,观察X综合征患者 (n =8)冠状静脉窦血浆内皮素浓度水平 ,同时与年龄、性别相匹配的健康人 (n =6 )作对照。结果 X综合征组在整个试验过程中 ,冠状静脉窦血浆内皮素浓度明显增加 (P <0 .0 5 ) ;并且在不同时点间的浓度均不同 (P <0 .0 5 )。结论 X综合征患者冠状循环内血浆内皮素浓度增高 。

Objective To study the relationship between vascular endothelial function and syndrome X. Methods Using atrial pacing techniques, the changes of endothelin concentration in coronary circulation were measured in 8 patients with syndrome X and 6 age matched normal subjects. Results In the syndrome X group, the changes of plasma endothelin were greater than those of the normal controls ( P <0.05). Conclusion The increase of plasma endothelin in coronary circulation in patients with syndrome X may suggest the presence of endothelial dysfunction.