血管紧张素原基因M235T多态性与冠心病关系的研究

Association between gene polymorphism of angiotensiongen(M235T) and coronary heart disease

目的 探讨中国苏皖地区人群血管紧张素原 (AgT)基因型的分布及其与冠心病(CHD)的关系。方法 应用突变基因分离聚合酶链 (MS PCR)技术 ,对 10 6例CHD患者、5 6例冠状动脉造影正常者以及 30名健康献血员AgT基因M2 35T多态性进行检测。 结果 病例组和对照组AgT基因型总体分布无显著差异 ,而病例组T等位基因频率 ( 0 788)显著高于对照组 ( 0 6 98) (P <0 0 5 )。结论 AgT基因M2 35T多态性中T等位基因是中国苏皖地区人群CHD发病的危险因素之一。

Objective To evaluate the association between the molecular variants of angiotensinogen(AgT) and the risk of coronary heart disease(CHD) in Chinese people from Jiangsu and Anhui provinces.Methods AgT(M235T) polymorphism was determined by means of mutagenically separated polymerase chain reaction(MS PCR) in 106 CHD patients identified by coronary angiography and the control group composed of 30 healthy subjects and 56 persons with normal coronary angiography results.Results There was an excess in the T allele of AgT gene in the case group and myocardial infarction(MI) group compared with control group ( P< 0 05) while the distribution of AgT genotype was not different significantly among case,MI and control groups.Conclusion The study suggests that AgT 235T allele should be a risk factor for CHD and MI in Chinese people from Jiangsu and Anhui provinces.