产科并发症与精神分裂症的病例对照研究

A case-control study for obstetric complications and schizophrenia

目的 探讨产科并发症与精神分裂症的关系 .方法 病例对照研究 ,单因素、多因素分析 ,并计算相对危险度和95 %的可信限 .结果 单因素分析显示 ,孕期并发症 (OR =4.6 3,95 % CI=1.2 7～ 2 0 .6 6 )、生产并发症 (OR=3.2 9,95 %CI=1.0 6～ 11.2 9)达到统计学意义 .性别分层分析 ,男性生产并发症发生率明显高于对照组 .多因素分析 ,孕期营养差、孕期并发症与精神分裂症有密切的关系 ,OR(95 % CI)分别为3.98(1.13～ 14.0 7) ,4.93(1.44～ 16 .86 ) .结论 精神分裂症的发生与孕期、生产期环境因素密切相关 ,孕期、生产期损伤者为精神分裂症的高危人群 .

AIM To investigate the relation between obstetric complications and schizophrenia. METHODS A case control study was conducted to analyze the odds ratio and 95% confidence interval for the history of obstetric complications by univariate and multivariate analyses respectively. RESULTS Univariate analyses showed that two risk fac tors, complications of pregnancy (OR=4.63, 95%CI=1.27~20.66) and complications of delivery (OR=3.29, 95%CI=1.06~11.29) had statistical significance. Rates of complications of delivery in male schizophrenia patients were more than that in controls. Multivariate analyses showed that schizophrenia was positively associated with poor nutrition of pregnancy (OR=3.98, 95%CI=1.13~14.07) and complications of pregnancy (OR=4.93, 95%CI=1.44~16.86). CONCLUSION Schizophrenia was positively associated with environmental factors of pregnancy and delivery. Schizo phrenic patients who had injuries of pregnancy and delivery are high risk population.