摘要
在心肌的梗塞(STEMI ) 是的尖锐圣片断举起以后的 statin 使用的 BackgroundThe 利益然而,很好证实预定 statin 管理的影响没被阐明。这研究的目的在经皮的冠的干预(一种总线标准) 以后集中了于早临床的结果学习包括了的心肌的梗塞登记(KorMI ) 上的朝鲜工作组的 .MethodsThis 分析 3,584 个 STEMI 病人(吝啬的年龄, 63 ±;13 年;男性, 2,684, 74.9%) 从 2008 年 1 月经历一种总线标准到 2009 年 6 月。主要不利心脏的事件的率(向:所有原因死亡,周期性的 MI,和目标损害 revascularization ) 在根据 statin 治疗预定组织的病人之中被比较:我,在期间并且在住院以后(n = 2,653, 74%) ;II,仅仅在住院期间(n = 309, 8.6%) ;III,仅仅在分泌物以后(n = 157, 4.4%) ;并且 IV,没有 statin 治疗(n = 465, 13%) 。吝啬的后续持续时间是 234 ±;statin 的 113 个 days.ResultsMultivariate 因素在住院期间使用包括的优先的 statin 使用,多重 diseased 容器,在心肌的梗塞流动等级 III 的最后的 thrombolysis,和低密度的脂蛋白胆固醇水平。在 6 月的后续,组 III 和 IV 有最高的向率(2.3% , 3.9% , 5.1% ,和 4.9% 为组 I-IV,分别地 P = 0.004 ) 。在为 confounders 调整以后,组 II-IV 比组有更高的向风险我[危险比率(HR ) :3.20, 95% 信心间隔(95%CI ) :1.31-7.86, P = 0.011;HR:3.84, 95%CI:1.47-10.02, P = 0.006;并且 HR:3.17, 95%CI:1.59-6.40, P = 0.001;分别地] 基于国家注册表数据库, .ConclusionsThis 学习早显示出早、连续的 statin 治疗 improvs 在在真实世界的临床的实践的一种总线标准以后的 STEMI 病人的结果。
Background The benefit of statin use after acute ST-segment elevation myocardial infarction (STEMI) has been well established, however, the influence of the timing of statin administration has not been elucidated. The objective of this study focused on early clinical outcomes after percutaneous coronary intervention (PCI). Methods This analysis of the Korea Working Group on Myocardial Infarction registry (KorMI) study included 3,584 STEMI patients (mean age, 63 ±13 years;male, 2,684, 74.9%) undergoing PCI from January 2008 to June 2009. Rates of major adverse cardiac events (MACE:all-cause death, recurrent MI, and target lesion revascularization) were compared among patients grouped according to statin therapy timing:I, both during and after hospitalization (n=2,653, 74%);II, only during hospita-lization (n=309, 8.6%);III, only after discharge (n=157, 4.4%);and IV, no statin therapy (n=465, 13%). Mean follow-up duration was 234 ± 113 days. Results Multivariate factors of statin use during hospitalization included prior statin use, multiple diseased vessels, final thrombolysis in myocardial infarction flow grade III, and low-density lipoprotein cholesterol level. At 6-month follow-up, groups Ⅲ and Ⅳ had the highest MACE rates (2.3%, 3.9%, 5.1%, and 4.9%for groups I-IV, respectively, P=0.004). After adjusting for confounders, groups Ⅱ-Ⅳ had a higher MACE risk than group Ⅰ [hazard ratio (HR):3.20, 95%confidence interval (95%CI):1.31-7.86, P=0.011;HR:3.84, 95%CI:1.47-10.02, P=0.006;and HR:3.17, 95%CI:1.59-6.40, P=0.001;respectively]. Conclusions This study, based on the national registry database, shows early and continuous statin therapy improvs early outcomes of STEMI patients after PCI in real-world clinical prac-tice.