浙江省11家哨点医院妇科患者人乳头瘤病毒感染情况及流行趋势

Prevalence and trends of human papillomavirus infections in gynecology patients from 11 sentinel hospitals in Zhejiang province

目的 了解浙江省女性患者人乳头瘤病毒（HPV）感染情况及流行趋势.方法 对2011年1月至2013年12月浙江省11家哨点医院妇科门诊就诊患者开展HPV监测.采用导流杂交技术检测21种HPV亚型.不同年份HPV感染情况和不同年龄组HPV感染率比较采用x2检验.结果 共纳入14 569例患者,其中HPV感染3 552例,感染率为24.38％.21种HPV亚型中,感染率居前3位的是HPV-16（5.77％,840/14 569）,HPV-52（4.71％,686/14 569）和HPV-58（4.52％,659/14 569）.单一高危型HPV感染率为15.40％（2 244/14 569）,单一低危型HPV感染率为2.92％（426/14 569）,多重HPV亚型感染率为6.05％（882/14 569）,其中多重HPV感染率呈逐年上升趋势（x2=23.65,P＜0.01）.15 ～ 24岁和＞54岁的患者HPV感染率最高,分别为27.91％（211/756）和27.73％（439/1 583）,与其他年龄组的感染率比较差异有统计学意义（x2=18.664,P＜0.01）.结论 浙江省妇科门诊患者HPV感染率较高,且多重亚型混合感染形势严峻,15 ～ 24岁和＞54岁为感染的高危人群.

Objective To investigate the prevalence and trends of human papillomavirus （HPV）infections in gynecology outpatients in Zhejiang province.Methods Samples of cervical exfoliated cells were collected from gynecology outpatients in 11 sentinel hospitals in Zhejiang Province from January 2011 to December 2013.Twenty one HPV subtypes were detected by flow-through hybridization technique.Chisquare test was performed to analyze the prevalence rates of HPV infections in different years and in different age groups.Results A total of 14 569 patients were enrolled in the study,among whom 3 552 （24.38%）were positive for HPV.HPV-16 （5.77%,840/14 569）,HPV-52 （4.71%,686/14 569） and HPV-58 （4.52%,659/14 569） were the most prevalent subtypes.Among all patients,2 244 （15.40%） were infected with a single high-risk subtype,426 （2.92%） were infected with a single low-risk subtype,and 882 （6.05%） were infected with multiple subtypes.The rate of multiple infection was on the rise during 2011 and 2013 （x2 =23.65,P 〈0.01）.The positive rates of HPV in patients with 15-24 y age group and 〉54 y age group were 27.91% （211/756） and 27.73% （439/1 583） respectively,which were higher than those in other age groups （x2 =18.664,P 〈 0.01）.Conclusion HPV infection is popular in gynecology outpatients in Zhejiang province,especially in patients aged 15-24 y and 〉 54 y,and a certain proportion of patients are infected with multiple subtypes.