摘要
目的 评估心肌梗死 (MI)患者及其同胞的冠心病易患因素及血脂异常相关基因ApoE的多态性。方法 对 6 5例确诊为MI的男性患者、141例同性别健康同胞及 47例年龄、性别相匹配的健康人进行流行病学问卷调查及临床检查 ,并从分子遗传学角度进行血脂异常相关基因ApoE多态性的检测 ,探索其与MI血脂异常的关系。结果 (1)MI组与同胞组总胆固醇 (TC) (分别为 5 0mmol/L± 1 8mmol/L、4 8mmol/L± 1 4mmol/L)、甘油三酯 (TG) (分别为 2 2mmol/L± 1 7mmol/L、1 97mmol/L± 0 2 6mmol/L)、低密度脂蛋白胆固醇 (LDL C)、TC/HDL C比值均显著高于对照组 (3 5mmol/L± 0 9mmol/L、1 1mmol/L± 0 9mmol/L) ,其中MI组BMI、LDL C、TC/HDL C比值明显高于同胞组 ;(2 )BMI>2 5kg/m2 、吸烟 >10支 /d、TC >5 2mmol/L、TG >2 2 6mmol/L、LDL C >3 4mmol/L、TC/HDL C >5 0、FBG >5 6mmol/L为冠心病的危险因素。 (3)血脂异常相关基因ApoE的三种基因型中 ,E3/3型基因最常见 ,但 3组基因型的分布频率及血脂、脂蛋白水平、粥样硬化指数等指标无统计学差异。 (4 )E4等位基因携带者MI患者约为非E4等位基因携带者的二倍。结论 血脂代谢紊乱是重要的冠心病易患因素 ,ApoE基因的多态性可能在遗传上间接成为冠心病的危险因素?
Objective To assess the risk factors of myocardial infarction (MI) and the polymorphism of the gene Apoliprotein (ApoE) genotype among MI patients and their siblings. Methods Questionnaire survey and clinical examination were conducted to 65 male MI patients, 141 “healthy” male siblings of the MI patients, and 47 healthy persons matched in age and sex. Results (1) The medians of TC, TG, LDL C, TC/HDL C in MI group and sibling group were higher than those in the control group with statistical significance. (2) BMI > 25 kg/m 2, cigarette > 10 /d, TC > 5 2 mmol/L, TG > 2 26 mmol/L, LDL C > 3 4 mmol/L,TC/HDL C > 5 0, and FBG > 5 6 mmol/L were risk factors for MI; and HDL C > 0 9 mmol/L was a protective factor for MI. (3) Among the three genotypes of ApoE, E3/3 was the commonest one. However, no significant difference was found in the distribution frequencies of these 3 genotypes, levels of serum lipid and lipoprotein, and TC/HDL C. (4) Among the MI patients the number of allele E4 carrier was nearly twice the number of the non allele E4 carrier. Conclusion Dyslipidemia is an important risk factor for MI, and polymorphism of ApoE may be an indirect risk factor of coronary heart disease genetically.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2001年第6期340-343,共4页
National Medical Journal of China
