新生儿缺血缺氧性脑病早期应用纳洛酮治疗的效果研究

Effect Research of Neonatal Hypoxic Ischemia Encephalopathy in the Early Application of Naloxone

目的探讨新生儿缺血缺氧性脑病早期给予纳洛酮治疗的疗效。方法对我院2011年1月至2013年9月间收治新生儿缺血缺氧性脑病患儿86例进行分析,随就诊时间先后分为研究组和对照组,每组患者各43例,研究组早期给予纳洛酮治疗,观察两组临床症状及体征消失时间、NBNA评分及治疗疗效。结果经1疗程治疗后,研究组呼吸改善、苏醒、惊厥消失、临床症状消失时间、NBNA评分均优于对照组,P<0.05,以总有效率88.37%高于对照组69.77%,P<0.05。结论以纳洛酮早期治疗新生儿缺血缺氧性脑病疗效优越,可迅速恢复患儿临床症状,提高NBNA评分,治疗时机应越早越好,避免形成不可逆损害。

Objective Neonates with hypoxic-ischemic encephalopathy early naloxone therapy. Methods In our hospital from January 2011 to September 2013 neonatal hypoxic ischemia encephalopathy in children with 86 cases were analyzed, and the time has been divided into research group and the control group（n=43）, the team early naloxone treatment, observation of two groups of clinical symptoms and signs disappeared time, NBNA score and the treatment effect. Results After 1 course of treatment, the team improve breathing, waking, convulsions disappear, clinical symptoms disappear time, NBNA scores were better than control group, P〈0.05, the total effective rate was 88.37% higher than the control group 69.77%, P〈0.05. Conclusion With naloxone treatment of neonatal hypoxic ischemia encephalopathy in the early curative effect is superior, can quickly recover with clinical symptoms, improve the NBNA score, treatment time should be the sooner the better, to avoid the formation of irreversible damage.