经济化疗方案对儿童低危急性淋巴细胞白血病短期疗效的影响

Influence of economic chemotherapy regimen on short-term effect in child patients with acute low-risk lymphoblastic leukemia

目的探讨经济化疗方案对儿童低危急性淋巴细胞白血病短期疗效的影响。方法收集本院确诊为儿童低危急性淋巴细胞白血病患者28例,将其随机分为研究组和对照组,研究组采用经济化疗方案,对照组采用常规化疗方案,对两组患者的临床疗效及总费用进行统计分析。结果研究组和对照组初治平均住院时间差异无统计学意义,研究组总费用明显低于对照组,差异有统计学意义(P<0.01)。研究组与对照组的D33骨髓反应及诱导治疗后完全缓解时间差异无统计学意义(P>0.05)。研究组的不良反应发生率明显低于对照组(P<0.05),两组1年内均未见复发。结论经济型化疗方案能在保证临床疗效的前提下大大降低了治疗费用,且不良反应较低,值得临床推广。

Objective To explore the influence of economic chemotherapy regimen on short-term effect in child patien risk In the research group,the economic chemotherapy regimen was provided,while in the control group,the conventional chemotherapy regimen was adopted.The clinical effect and total cost in both groups were statistically analyzed. Results There was no significant difference in average hospital stay during initial treatment in both groups. The total cost in the research group was lower than that in the control group with a statistical difference （P〈0.01）.There was no statistical difference in complete remission time after D33 myeloid reaction and inductive treatment in the two groups （P〉0.05）. Adverse reaction in the research group was greatly lower in comparison with that in the control group （P〈0.05）.There was no recurrent case within one year in each group. Conclusion Economic chemotherapy regimen at premise of ensuring the clinical effect can greatly reduce the cost and its adverse reaction is lower,which is worthy of expansion in clinic.