IL-1β基因-31C/T位点多态性与子痫前期的相关性

ASSOCIATION OF INTERLEUKIN-1β-31C/T SINGLE NUCLEOTIDE POLYMORPHISM WITH PREECLAMPSIA

目的 探讨白细胞介素-1β基因-31C/T（rs1143627）位点单核苷酸多态性与子痫前期发病的关系。方法 选取200例子痫前期病人和300例正常妊娠者，检测并比较两组体质量指数（BMI）、血压、24 h尿蛋白定量、白细胞介素-1β基因-31C/T多态性及基因型频率分布差异。结果 两组BMI差异无显著性（P〉0.05）；子痫前期组血压、24 h尿蛋白定量高于正常妊娠组，差异有显著性（t=15.58-21.27，P〈0.01）；子痫前期组白细胞介素-1β基因-31T/T、-31C/T及-31C/C基因型频率分布及等位基因C、T频率比较差异无显著性（P〉0.05）。结论 白细胞介素-1β-31C/T位点基因多态性可能与子痫前期的发生无显著性关联。

Objective To explore the association of single nucleotide polymorphism of the C/T （rsl143627） genetic locus of IL-1β gene with preeclampsia. Methods This study consisted of 200 preeclampsia patients and 300 normal pregnant women. The parameters concerned were detected and compared between the two groups in terms of the following items： BMI, blood pressure,24-hour urine protein, single nucleotide polymorphism of IL-1β-31C/T and distribution of genotype frequency. Results There was no statistical difference with regard to BMI between the two groups （P〉0.05）, as for blood pressure and 24-hour urine protein levels, which were higher in the patients than the normal pregnancies （t=15.58-21.27,P〈0.01）. There was no statistically difference in IL-1β-31C/T genotype distributions as well as allele frequencies between preeclampsia patients and the controls （P〉0.05）. Conclusion It is likely that single nucleotide polymorphisms of IL-1β-31C/T do not significantly correlate with the development of preeclampsia.