肥胖儿童血清C反应蛋白与代谢综合征的相关性研究

The relationship between C-reactive protein and metabolic syndrome in obese children

目的探讨肥胖儿童血清CRP与发生代谢综合征的相关性。方法检测48例10岁肥胖儿童血清CRP水平，并与36例健康体检的同龄健康儿童进行对比，比较两组间的差异，并分析其与代谢综合征关键因素间的相关性。结果肥胖组儿童血清胰岛素、TG、TC、CRP、BMI、收缩压、胰岛素抵抗指数（HOMA-IR）[分别为（16．1±3．7）mU／L、（1．38±0．29）mmol／L、（4．79±0．88）mmol／L、（1．83±0．89）mg／L、（28．7±5．3）kg／m^2、（129．4±11．3）mmHg、（3．81±0．92）]均显著高于健康儿童[分别为（10．4±2．8）mU／L、（0．75±0．12）mmol／L、（4．12±0．65）mmol／L、（0．78±0．22）mg／L、（22．4±3．9）kg／m^2、（117．2±8．9）mmHg、（2．37±0．78）]（t=7．727、12．260、3．846、6．912、6．012、5．349、7．568，均P〈0．05）；Spearman相关分析显示，CRP与胰岛素、TG、BMI、收缩压、HOMA-IR呈正相关（r=0．693、0．293、0．525、0．212、0．195，均P〈0．05）。结论肥胖儿童血清CRP水平显著升高，且与代谢综合征的发生密切相关。

Objective To investigate the relationship of the C-reactive protein （CRP） and metabolic syn- drome. Methods The serum level of CRP was determined in 48 cases of obese children and 36 cases of healthy indi- viduals. All children were 10 years old. The differences between the two groups and whether CRP was associated with metabolic syndrome were analyzed. Results The obese children had significant higher serum insulin, TG, TC, CRP, BMI, SBP and HOMA-IR[ for respectively （ 16. 1 ±3.7 ） mU/L, （ 1.38 ± 0.29 ） mmol/L, （ 4.79 ± 0.88 ） mmol/L, （ 1.83 ± 0.89 ） mg/L, （28.7±5.3 ） kg/m^2, （ 129.4± 11.3 ） mmHg, （3.81± 0.92） ] than those of the normal controls [for respectively（10.4 ±2.8）mU/L,（0.75±0.12） mmol/L, （4.12± 0.65） mmol/L, （0.78 ±0. 22） mg/L, （22.4 ± 3. 9）kg/m^2, （117.2 ±8.9）mmHg, （2.37 ±0. 78） ] （t = 7.727,12. 260,3. 846,6. 912,6. 012,5. 349,7.568 ,all P 〈 0. 05 ）. The results of correlation analysis showed that CRP had a positive correlation with serum insulin, TG, BMI, SBP and HOMA-IR （r=0.693,0.293,0.525,0.212,0. 195,all P〈0.05）,but not TC. Conclusion There are significant increases of serum CRP level in obese children, and the increased CRP was closely related with metabolic syndrome.