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2,2＇,4,4＇-四溴联苯醚的生物转运和转化对其毒效应的影响

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摘要 多溴联苯醚（polybrominated diphenyl ethers,PBDEs）是一类重要的溴代阻燃剂,广泛应用于电子电气设备、塑料制品、纺织品与生活用品中,主要有五溴联苯醚、八溴联苯醚和十溴联苯醚3种工业用品.2009年,PBDEs被斯德哥尔摩公约列为新型的持久性有机污染物（persistent organic pollutants,POPs）.随着PBDEs的大量使用,大气、水、土壤、污泥沉积物甚至生物体中都能检测到PBDEs,且含量逐年增加.2,2 ＇,4,4’-四溴联苯醚（2,2 ＇,4,4’-tetrabromodiphenyl ether,BDE47）是人体内最主要的PBDEs同系物,可通过消化道、呼吸道以及皮肤接触暴露于该化合物.研究显示,0～3岁婴幼儿暴露水平最高,平均每天约为227 pg/kg,其次为儿童和成年人.
作者 张展 李书书 孙真真 王守林
机构地区 南京医科大学公共卫生学院现代毒理学教育部重点实验室
出处 《中华预防医学杂志》 CAS CSCD 北大核心 2014年第7期651-654,共4页 Chinese Journal of Preventive Medicine
基金 国家重点基础研究发展计划（2009CB941701） 国家自然科学基金（81172695,81372956） 江苏省研究生创新计划（CXZZ12_0599）
关键词 多溴联苯醚 生物转运 毒效应 持久性有机污染物 转化 生活用品 暴露水平 五溴联苯醚
分类号 R114 [医药卫生—卫生毒理学]
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参考文献44

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二级参考文献32

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中华预防医学杂志
2014年 第7期

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