骨组织工程用磷酸八钙复合材料的研究进展

Advances in octacalcium phosphate composites for bone tissue engineering

磷酸八钙被认为是骨组织中羟基磷灰石的前驱相,拥有优良的生物降解性、更好的骨传导性和诱导性,是一种重要的骨替代材料。文中详细介绍了磷酸八钙的制备方法,阐述其与胶原、明胶、海藻酸钠、壳聚糖、丝素蛋白等有机材料结合形成复合材料的性能,以及其在骨组织工程中的应用。

Octacalcium phosphate （OCP） is supposed to be a precursor of hydroxyapatite in bone tissue. As an important bone replacement material, it possesses excellent biodegradability, better bone conduction and osteoinduction. Recent progress on the experimental attempts to fabricate pure OCP and OCP- based composite materials, such as combined within collagen, gelatin, alginate, chitosan and silk fibroin are reviewed, as well as their performance and applications in bone tissue engineering.