缰核在中枢奖赏调控的机制及其在精神疾病中的作用研究进展

Advances of mechanism of habenula in reward and its role in mental illness

缰核是一个在生物进化过程中古老且保守的中枢核团,参与许多重要的生物学功能,如母性行为、疼痛、睡眠、应激、学习和奖赏等。作为多巴胺奖赏网络中一个重要的节点,缰核在奖赏(也包括维持个体生存的趋利避害)过程中的功能和作用机制近年来引起学术界的广泛关注并成为研究的热点中枢核团之一。缰核的功能紊乱与许多精神疾病如抑郁、精神分裂症、成瘾等密切相关,也可能成为这些精神疾病临床治疗的潜在靶点。阐明缰核在奖赏和觅药动机中的作用和神经生物学机制具有重要的理论意义和临床应用价值。

The habenula complex,an ancient and conservative nucleus during biological evolution,is involved in many important biological functions,such as maternal behavior,pain,sleep,learning and reward. As an important node in the dopamine reward network,its functions（ including the maintenance of individual survival while avoiding disadvantages） and mechanism in the reward process have attracted wide attention. The dysfunction of habenula is closely related to many psychotic disorders,such as depression,schizophrenia and drug habituation. Habenula may also become a potential target for clinical treatment of these mental illnesses. So clarifying the role and neurobiological mechanisms of habenula in the central nervous system is of great theoretical and clinical value.