药用植物提取物抑制钙调磷酸酶活性作用的研究进展

Progress of inhibitory effect of medicinal plant extracts on calcineurin

钙调磷酸酶抑制剂如环孢素A和他克莫司是目前临床上常用的免疫抑制剂,但具有肾毒性、高血糖等多种不良反应。从药用植物中提取筛选钙调磷酸酶抑制剂为开发新的高效低毒免疫抑制剂提供了一条新途径。研究表明,聚异戊二烯二苯甲酮类化合物isogarcinol、槲皮素、山奈酚、苯乙醇苷类化合物、艾里莫芬烷倍半萜类化合物eremoxylarins A和eremoxylarins B以及扁柏提取物、菝葜提取物和矮探春提取物等对钙调磷酸酶活性具有明显的抑制作用。本文对近年来药用植物提取物抑制钙调磷酸酶活性作用的研究进行综述,旨在为利用和开发药用植物来源的钙调磷酸酶抑制剂提供参考。

Calcineurin inhibitors,such as cyclosporin A and tacrolimus,are widely-used immunosuppressive drugs clinically. However,renal toxicity,hyperglycaemia and other side-effects can occur over long-term use. Isolation of novel calcineurin inhibitors from medicinal plants in recent years has provided a new approach to the development of new immunosuppressive drugs with high efficiency and low toxicity. Recnt studies have shown that medicinal plant extracts,such as isogarcinol,quercetin,kaempferol, phenylethanoid glycosides,eremophilane sesquiterpenes A and B,pisiferdiol,as well as extracts from Smilax china L and Jasminum humile L,have obvious inhibitory effect on calcineurin.