感染对急性脑梗死患者短期预后的影响

Effects of post stroke infection on short-term outcomes of acute cerebral infarction patients

目的探讨急性脑梗死后感染的发生率、危险因素以及对短期预后的影响。方法对确诊急性缺血性脑卒中的住院患者进行评估,入院的第1 d记录患者的基本情况、严重程度、生理参数以及实验室检查指标,第7 d记录感染和预后。结果共有432例患者纳入研究,79例在7 d内出现感染(18.3%)。下列情况更容易发生感染:(1)高龄;(2)大面积脑梗死;(3)入院前无独立生活能力;(4)昏迷;(5)导尿;(6)吞咽困难。脑梗死后感染与住院期间7 d的病死率明显相关。结论急性缺血性脑卒中后感染可以影响短期预后。

Objective To investigate the incidence, risk factors and effects on short-term clinical outcomes of post stroke infection. Methods Patients with acute cerebral infarction were investigated in this study. On day 1, we recorded the patients＇ baseline characteristics, stroke subtype and severity, physiological parameters, and laboratory results. On day 7, we recorded the occurrence of complications including infections and functional outcomes. Results 432 patients were included in this study, 79 patients （18.3%） had infection by day 7. Compared to patients without infection, the patients with following situations are more prone to infection： （ 1 ） being older; （2） massive cerebral infarction; （3） independent living skills before admission; （4） coma; （5） having urinary catheters; （6） dysphasia; After adjusting for case mix, infection was significantly correlated to in-hospital death during 7 days. Conclusions Post-stroke infection could induce poor short-term outcomes of acute cerebral infarction patients.