急性脑梗死患者血清MMP-2的动态变化及其临床意义

Dynamic changes of serum MMP-2 and clinical significance in patients with acute cerebral infarction

目的探讨急性脑梗死(ACI)患者血清基质金属蛋白酶-2(MMP-2)的动态变化及其临床意义。方法采用ELISA法检测120例ACI患者(A组)发病后1、3、7、14d和150例健康人(B组)血清MMP-2水平,分析其血清水平的动态变化及临床意义。结果 A组发病后第1、3、7和14天血清MMP-2为(45.62±5.94)ng/ml、(69.63±6.33)ng/ml、(58.65±6.84)ng/ml和(53.53±6.22)ng/ml(P<0.05),均高于B组的(32.33±4.53)ng/ml。ACI患者血清MMP-2水平与脑梗死面积和神经功能缺损程度呈正相关(P<0.05)。结论 ACI发生后,血清MMP-2水平明显升高,且与神经功能缺损程度密切相关;血清MMP-2水平可作为ACI的临床诊断和评估病情的监测指标之一。

Objective To explore the dynamic changes of serum matrix metalloproteinase-2 （MMP-2） and clinical significance in patients with acute cerebral infarction（ACI）. Methods With ELISA method,serum levels of MMP-2 were detected in 120 patients with ACI（group A） on the 1st, 3rd ,7th and 14th day after attack and in 150 healthy people（group B） as the controls. The dynamic changes of MMP-2 and clinical significance in ACI patients with different severities were analyzed. Results Serum levels of MMP-2 in group A were （45.62±5.94） ng/ml, （69.63±6.33） ng/ml, （58. 65±6.84） ng/ml and （53.53±6.22） ng/ml on the 1st, 3rd, 7th and 14th day after attack, respectively（P^0. 05）, which were significantly higher than （32.33±4. 53） ng/ml in group B （P〈0. 05）. Serum level of MMP-2 in group A was positively correlated with the area of cerebral infarction and the severity of neurologic deficits（P〈0. 05）. Conclusion Serum level of MMP-2 is significantly elevated in the patients with ACI, which is positively correlated with the area of cerebral infarction and the severity of neurologic deficits and may be taken as an indicator for the diagnosis and illness evaluation.