健康献浆员破伤风抗体水平调查分析

Investigation on tetanus antibody levels in healthy plasma donors

目的 调查湖北省松μ市健康献浆员的破伤风抗体水平。方法 在松μ单采血浆站健康献浆员中,采用随机表法抽取18～55岁不同年龄人群539人,分为≤35、36～40、41～45、46～50、51～55岁共5个年龄组,收集单采血浆样本,采用间接ELISA法检测血清中破伤风抗体水平。结果539人中抗体达保护水平的479人,破伤风抗体阳性率为88.9%,抗体总体平均含量（average total content,ATC）为（2.350±3.246）IU/ml;各年龄组破伤风抗体阳性率均接近90%,差异无统计学意义（P〈0.05）,其中≤35岁年龄组阳性率最高,为89.8%,51～55岁年龄组最低,为87.8%,46～50岁年龄组ATC最高,为（2.622±3.518）IU/ml,51～55岁年龄组最低,为（1.870±2.947）IU/ml;除41～45与51～55岁年龄组抗体水平分布差异有统计学意义（P〉0.05）外,其他年龄组间差异均无统计学意义（P〈0.05）;不同性别组间抗体阳性率及抗体水平分布差异均无统计学意义（P均〈0.05）。结论 松μ市18～55岁健康人群除少部分人外,基本均具有抗破伤风的免疫力。

Objective To investigate the tetanus antibody levels in healthy plasma donors in Songzi City, Hubei Province, China. Methods A total of 539 healthy plasma donors in Songzi City, at ages of 18 - 55 years, were randomly selected and divided into five age groups （not more than 35, 36 - 40, 41 -45, 46 - 50 and 51 - 55 years）, of whom plasma samples were collected and determined for serum tetanus antibody level by indirect ELISA. Results The tetanus antibodies of 479 of the 539 donors reached protective levels, with a positive rate of 88. 9% and an average total content （ATC） of （2. 350 ± 3. 246 ） IU/ml. The tetanus antibody positive rates in various groups were nearly 90%, which showed no significant difference （P 〉 0. 05 ）. The positive rate in the donors at ages of not more than 35 years was the highest （89. 8%）, while that in those at ages of 51 - 55 years was the lowest （87. 8%）. However, the ATC was the highest in the donors at ages of 46 - 50 years [（2. 622± 3. 518） IU/ml], while was the lowest in those at ages of 51 - 55 years [ （ 1. 870 ± 2. 947） IU/ml]. The distributions of antibody levels in the donors at ages of 41 - 45 and 51 - 55 years showed significant difference （P 〈 0. 05 ）, while those in other age groups showed no significant difference （P 〉 0. 05 ）. Conclusion Most of healthy adults at ages of 18 - 55 years in Songzi City showed the immunity against tetanus.