PD-1抗体在肿瘤治疗中的应用

Application of PD-1 antibody in therapy of tumors

肿瘤通过刺激免疫系统的抑制受体改变原有免疫反应,进行免疫逃逸。通过阻断T细胞抑制受体,阻断肿瘤的发生,为抗肿瘤免疫提供了潜在的治疗方法。PD-1(programmed death-1)是T细胞抑制受体,在T细胞功能性紊乱时持续表达,其可作为停止信号在肿瘤中限制T细胞的效应功能。阻断PD-1信号可有效帮助衰竭T细胞,促进抗肿瘤免疫应答。PD-1抗体在癌症治疗及免疫刺激中具有重要作用,本文就PD-1及其配体、PD-1/PD-Ls信号通路以及PD-1抗体在肿瘤治疗中的应用作一综述。

Tumors are closely related to immune system and they can escape immune surveillance by stimulating immune inhibitory receptors, which can be blocked by the inhibitory receptors on the T cell. This provides a potential method for anti-tumor immune therapy. PD-1 is an inhibitory receptor with sustained expression in T cell dysfunction, of which the primary function is to limit the T cell effector as the stop signal. Blocking PD-1 signal is effective in helping exhausted T cells, which plays an important role in promoting the anti-tumor immune response. This review summarizes PD-1 and its ligands, PD-1/PD-Ls signaling pathway as well as the application of PD-1 antibody in the therapy of tumors.