IL-4基因多态性与乙型肝炎疫苗反应相关性的荟萃分析

Association of Polymorphisms in the Interleukin-4 Gene with Response to Hepatitis B Vaccine: a Meta-analysis

目的评价白细胞介素-4(IL-4)基因多态性与个体对乙型肝炎疫苗反应的相关性。方法在PubMed、Embase、Web of Science和China Bio Medicine(CBM)数据库中对2012年12月1日前发表的文献作关键词检索。应用STATA12.0软件对文献中的数据进行荟萃分析。结果经全面检索,共纳入5篇文献,均为横断面研究。Meta分析结果显示,IL-4的T等位基因rs2243250、rs2070874和C等位基因rs2227284与乙型肝炎疫苗的高反应性相关。进一步依据种族进行的亚组分析显示,亚洲人群中IL-4基因多态性与乙型肝炎疫苗的反应性明确相关,但在高加索人群中则未发现这种相关性。结论个体对乙型肝炎疫苗的反应性与IL-4基因多态性相关,相关位点为T等位基因rs2243250、rs2070874和C等位基因rs2227284。并且这种相关性有明显的人种差异。

Objective The aim of this meta - analysis is to evaluate the associations between functional polymorphisms in the interleukin -4 （IIA） gene and individuals＇ responses to hepatitis B vaccine. Methods A literature search on articles published before December 1st, 2012 was conducted in PubMed, Embase, Web of Science and China Bio Medicine （CBM） databases. Crude odds ratios （ORs） with 95% confidence intervals （CIs） were calculated. Statistical analyses were performed using the STATA 12. 0 software. Results Five cross - sectional studies on individual＇s response to hepatitis B vaccine were eligible for inclusion in this meta - analysis. The meta - analysis results showed that the T allele of rs2243250, the T allele of rs2070874, and the C allele of rs2227284 inIIAgene were associated with high responses to hepatitis B vaccine. Further subgroup analysis by ethnicity showed that there was a significant association betweenIL4 genetic polymorphisms and an individual＇s responses to hepatitis B vaccine among Asian populations, but similar association was not found among Caucasian populations. Conclusion Our current meta - analysis suggests that rs2243250, rs2070874 and rs2227284 polymorphisms in IIA gene may play an important role in determining the response to hepatitis B vaccine, especially among Asian populations.