血清淀粉样蛋白A对早期胃癌诊断的研究

Effect of Serum Amyloid A in Diagnosis of Early Gastric Cancer

目的 考察血清淀粉样蛋白A对早期胃癌诊断的意义.方法 收集2009年5月～2013年1月在笔者医院消化外科住院早期胃癌患者71例,并选同期治疗的胃溃疡病患49例为对照.结果 与胃溃疡组相比,早期胃癌组的C反应蛋白（C-reactive protein,CRP）和血清淀粉样蛋白A（serum amyloid A,SAA）表达较高,具有统计学差异（P＜0.05）.早期胃癌不同性别和不同年龄组间的CRP和SAA表达无统计学差异（P＞0.05）;早期胃癌病患的肿瘤大小组间的CRP无统计学差异（P＞0.05）,早期胃癌病患的肿瘤大的SAA表达较高（P＜0.05）;早期胃癌病患的浸润深度高、肿瘤特殊分化和淋巴转移组间的CRP和SAA表达较高（P ＜0.05或P＜0.01）.术后,早期胃癌病患组CRP阳性术前63例（88.7％）降至术后19例（26.8％,P＜0.05）,SAA阳性术前63例（88.7％）降至术后24例（33.8％,P ＜0.05）,术后CRP和SAA阳性表达无统计学差异（P＞0.05）.结论 血清SAA检测对早期胃癌的浸润、大小、分化和转移的评估和术后预测具有重要的临床意义.

Objective To investigate the significance of serum amyloid A（SAA） in diagnosis of early gastric cancer. Methods From May 2009 to January 2013, 71 cases early gastric cancer in our hospital underwent operation were enrolled in our study. Totally 49 cases of ulcer patients were chosen as control at the same time. Results Compared with control group, CRP and SAA expressed in early gastric cancer group were higher （ P 〈 0.05）. In early gastric cancer group, CRP and SAA had no relationship with gender and age （ P 〉 0. 05 ）. CRP had no relationship with tumor size （ P 〉 0. 05 ） , but SAA had （ P 〈 0. 05 ）. CRP and SAA were expressed different in inva- sion depth, differentiation and metastasis （ P 〈 0.05 or P 〈 0. Ol ）. Compared with pre - operation group, CRP expression was reduced from 63 cases （88.7%） to 19 cases （26.8%） , and SAA expression was reduced from 63 cases （88.7%） to 24 cases（26.8% ） after operation （ P 〈 O. 05）. The expression of CRP and SAA after operation were no different （ P 〉 0. 05 ）. Conclusion Detection of SAA was help of diagnosis of early gastric cancer. The invasion, size, differentiation and metastasis assessment and postoperative prediction can be analyzed in early gastric cancer.