子痫前期孕妇血细胞比容、sVEGFR-1水平与围生儿结局比较

Comparison Between Preeclampsia Hematocrit,Soluble Vascular Endothelial Growth Factor Receptor-1 and Perinatal Outcomes

目的 通过对子痫前期患者产前血细胞比容（HCT）、血中sVEGFR-1水平的改变探讨其对围生儿结局的影响.方法 对2011年7月～2012年1月在辽宁朝阳市中心医院入院的41例子痫前期患者和19名正常妊娠者采集一般状况,用电子血细胞自动计数仪测静脉血的血细胞比容;采用酶联免疫测定（ELISA）试剂盒检测血清中sVEGFR-1水平.记录所有胎儿出生体重、Apagar评分,用Pearson检验进行相关性分析.结果 子痫前期组与正常妊娠组比较,孕期明显缩短（P ＜0.001）.无论收缩压还是舒张压均明显高于正常妊娠组（P ＜0.001）,子痫前期组HCT明显增高（P＜0.001）,血清sVEGFR-1水平亦明显升高（P＜0.05）,其中子痫前期早发型升高最显著（P ＜0.001）,23例早发型组中7例采用引产终止妊娠.围生儿出生体重子痫前期组明显低于正常新生儿组（P＜0.05）,其中以早发型组最低,与正常或晚发型组差异明显（P＜0.001）.此外,产后1min的Apagar评分正常新生儿19例全部是满分（10分）,明显高于子痫前期组（P＜0.001）.Pearson检验显示,产前孕妇血清sVEGFR-1水平与围生儿出生体重呈明显的负相关（P＜0.01,r=-0.54）.结论 本研究发现子痫前期HCT明显增高,产前孕妇血中sVEGFR-1水平与围生儿出生体重呈明显负相关,对预测子痫及其母婴预后有重要参考价值.

Objective To compare Hematocrit（HCT） , Soluble Vascular Endothelial Growth Factor Receptor - 1 （ sVEGFR - 1 ） in pregnant women with preeclampsia and perinatal outcomes. Methods Folty - one preeclamptic patients and nineteen normal pregnantwomen in Chaoyang Central Hospital, Liaoning province from July 2011 to January 2012 were enrolled in the study. Automatic counting cell instrument was used for measuring HCT in the venous blood. The serum sVEGFR - 1 levels in all the subjects were analyzed with ELISA method respectively. All fetal birth weight, Apagar score were also recorded. The correlation analysis was performed with Pearson test. Results Pregnancy was significantly shorter （P 〈 0. 001 ） in Preeclampsia when compared with normal pregnancy group. Either systolic or diastolic blood pressure was significantly higher than that of normal pregnancy group （P 〈 0. 001 ）. HCT significantly increased （P 〈0.001 ） in preeclampsia group. The serum sVEGFR- 1 was also significantly higher （P 〈 0. 05 ）. The early onset preeclampsia increased most significantly （ P 〈 0. 001 ）. 7 cases of termination of pregnancy in 23 - early onset group were used by induced abortion. Peri- natal birth weight in preeclampsia group were significantly lower than those in normal neonate group （P 〈 0.05 ）. The early onset group was the lowest, when compared with normal or late onset group （P 〈0. 001 ）. In addition, Apagar score of postpartum lmin in 19 normal neonates was full mark （10） , higher than those in preeclampsia group （P 〈0. 001 ）. Pearson test showed that serum sVEGFR - 1 levels in pregnant women were obviously negatively correlated with perinatal birth weight （P 〈 0.01, r = - 0.54）. Conclusion This study found that HCT of preeclampsia was significantly higher,sVEGFR - 1 levels in the blood of pregnant women were obviously negatively correlated with perinatal birth weight, which could be beneficial for predicting the preeclampsia prognosis and perinatal outcome.