Gli1和OPN在结直肠癌组织中的表达及其临床意义

Expression and Clinical Significance of Gli1 and OPN in Colorectal Cancer

目的探讨脑胶质瘤相关癌基因(glioma-associated oncogene1,Gli1)和骨桥蛋白(osteopontin,OPN)在结直肠癌组织中的表达情况及临床意义。方法应用免疫组化SP法检测Gli1和OPN蛋白在76例结直肠癌组织,23例正常结直肠组织中的表达情况,分析Gli1和OPN与结直肠癌患者的临床病理因素之间的关系以及二者之间表达的相关性。结果 (1)Gli1在结直肠癌组织和正常结肠组织中表达的阳性率分别为43.4%(33/76)和13.0%(3/23),两者差异具有统计学意义(P<0.05);OPN在结直肠癌组织和正常结肠组织中表达的阳性率分别为51.3%(39/76)和17.4%(4/23),差异有统计学意义(P<0.05)。(2)Spearman等级相关分析提示,Gli1和OPN在结直肠癌组织间的表达呈正相关(r=0.312,P<0.01)。结论 Gli1和OPN参与了结直肠癌的发生发展过程,二者之间可能起协同作用,联合检测Gli1和OPN对于评估结直肠癌的生物学特性和判断预后具有一定价值。

Objective To investigate the expression and clinicopathologieal significance of Glil and OPN protein in colorectal cancer and normal colorectal tissues. Methods Immunohistochemistry SP method was used to detect the expression of Glil and OPN in 76 cases of colorectal cancer tissues and 23 normal colorectal tissues, and analyze the relationship between the expression and clinicopathological parameters, and the correlation between Glil and OPN expression. Results （1） The expression of Glil in colorectal cancer tissues and normal colorectal tissues were 43.4% （33/76） and 13.0% （ 3/23 ） , The expression of Glil in colorectal cancer tissues and normal colorectal tissues were 51.3% （39/76） and 17.4% （4/23）. Both difference had statistical significance （ P 〈 0.05 ）. （ 2 ） Positive relation was seen between the expression of Glil and OPN by Spearman analyze. Conclusion Glil and OPN were involved in the tumorigenesis and development of colorectal cancer. They might play a synergetic effect in the process. The joint detection of Glil and OPN might be regarded as much value to evaluate the biological features and judge the prognosis of colorectal cancer.