不同产地金樱子的根和根茎免疫调节活性研究

Study on immunomodulatory activity of root and rhizome of Rosa laevigata from different habitats

目的对广西、云南、贵州3个产地的金樱子的根和根茎样品的免疫调节活性进行评价。方法采用小鼠迟发性超敏反应、小鼠溶血素抗体生成以及小鼠碳粒廓清试验,分别考察对细胞免疫、体液免疫和非特异性免疫的影响。结果金樱根提取物对于细胞免疫、体液免疫具有较明显的抑制作用,但对非特异性免疫反应作用不明显。金樱子不同药用部位(根和根茎)和不同产地(广西、贵州、云南)的受试样品在免疫活性调节方面的作用基本一致,无显著差异。结论不同部位和不同产地金樱子样品具有相似的的免疫抑制活性。

Objective To evaluate the immunomodulatory activity of the roots and rhizomes in Rosa laevigata（Rosa Laevigata Radix） in Guangxi,Yunnan,and Guizhou provinces.Methods The effects of cellular immunity,humoral inmunity,and non-specific immunity were investigated on delayed-type hypersensitivity,serum hemolysin antibody,and carbon clearance of mice,respectively.Results Rosa Laevigata Radix could inhibit the delayed-type hypersensitivity and serum hemolysin antibody in mice,but had no effect on carbon clearance.All the roots and rhizomes of R.laevigata from different habitats had no statistically significant difference on immunomodulatory activity.Conclusion The roots and rhizomes of R.laevigata from different habitats have the similar immunosuppressive activity.