人参皂苷Rg_1、Rb_1及其代谢产物益智作用的研究进展

Nootropic effect of gensenosides Rg_1 and Rb_1 and their metabolites

人参皂苷是人参的主要活性成分,人参皂苷具有许多药理作用,其益智作用是其药理作用的重要方面。在各种皂苷中,以人参皂苷Rg1和Rb1的量最高。综述人参皂苷Rg1、Rb1对动物学习记忆行为的影响、动物不同脑区的作用、中枢神经递质的影响,以及对学习记忆相关信号通路的作用,总结人参皂苷Rg1、Rb1的益智作用,并对其代谢产物的益智作用进行简要介绍。

As the main active ingredients of ginseng,ginsenosides have many pharmacologic effects,and the nootropic effects are the important pharmacologic action of ginsenosides.Among all of the ginsenosides,the contents of ginsenosides Rg1 and Rb1 are the highest.The nootropic effects of ginsenosides Rg1,Rb1,and their metabolites are summarized in this paper following four aspects：the effects of ginsenoside Rg1 and Rb1 on the animal behaviors,their effects on different brain regions in rodents,the effects on neurotransmitters,and their effects on signaling pathway on learning and memory.The nootropic effects of their metabolites are also mentioned.