清洁手术患者抗菌药物使用调查分析

Investigation and analysis about utilization of antibacterials in patients undergoing aseptic operation

目的分析3所医院清洁手术预防使用抗菌药物的情况及不合理应用的主要原因,为临床合理应用抗菌药物提供参考。方法对2012年6-12月3所医院手术患者1 374例,采用回顾性分析的方法,对Ⅰ类切口手术抗菌药物品种选择、给药时机、疗程、联合应用及更换等进行统计分析。结果 3所医院手术患者使用抗菌药物共1 028例,平均使用率为74.82%;使用频度位居前3位的抗菌药物为头孢西丁、头孢曲松、头孢呋辛;疗程最短24h,最长7d,平均用药时间为(4.31±1.07)d;单一抗菌药物使用461例占33.55%,二联抗菌药物使用359例占26.13%,单一品种更换208例占15.14%。结论清洁手术预防应用抗菌药物存在使用率高、药物种类选择不当、用药时间过长、无指征联合用药等不合理现象。

OBJECTIVE To analysis the status of the utilization of the prophylactic antibiotics and the main reason for the irrational use in patients undergoing aseptic operation of three hospital in our city,so as to provides the referential evidence for the utilization of the prophylactic antibiotics in clinic.METHODS Retrospective analysis was carried out to 1374patients in the three hospitals from Jun.to Dec.2012and the status of the utilization of the prophylactic antibiotics in patients undergoing aseptic operation include drug varieties;drug administration time,course of treatment,drug combination and change etc was analyzed statistically.RESULTS A total of 1028cases of patients in the three hospitals were taking antibiotics and the average using ratio was 74.82%,leading the first three places in terms of DDDs were cefoxitin,ceftriaxone sodium and cefuroxime.Treatment was continued for a minimum of 24hand a maximum of 7day,the average use time was（4.31±1.07）d,The use of a single species of antibiotics were 461cases,accounting for 33.55%,two kinds of antibacterial drugs 359cases,accounting for26.13%,single variety replacement 208cases,accounting for 15.14%.CONCLUSIONThere were irrational situation including high usage,irrelevant drug varieties,lengthy drug administration time,drug combination in the prophylactic antibiotics in patients undergoing aseptic operation.