中药对痰瘀阻肺型肺癌化疗及感染治疗效果分析

Clinical efficacy of Chinese medicine combined with chemotherapy in treatment of phlegm-stasis blocking lung cancer and treatment of infections

目的探讨葶苈大枣泻肺汤与导痰汤联合化疗对痰瘀阻肺型肺癌临床疗效及感染控制的作用。方法选择2007年1月-2010年1月住院治疗的中晚期肺癌患者114例,按照随机数字表法分为观察组64例,对照组50例,两组患者采用相同的化疗方案,观察组在化疗的基础上加用中药方剂,比较两组的疗效、患者免疫功能、不良反应以及肺部感染的发生率。结果近期疗效比较,总有效率对照组为54.0%、观察组为79.7%,两组比较差异有统计学意义(P<0.05);治疗后1、3年的存活率观察组92.2%、69.9%,对照组76.0%、34.0%,两组比较差异有统计学意义(P<0.05);免疫功能水平观察组化疗后与化疗前比较差异有统计学意义(P<0.05),不良反应发生率观察组50.0%,显著低于对照组的80.0%(P<0.05);观察组肺部感染发生率为46.9%,显著低于对照组的74.0%(P<0.05)。结论葶苈大枣泻肺汤与导痰汤对痰瘀阻肺型肺癌化疗患者能够显著提高化疗效果,提高患者生存率,增强患者的免疫功能、降低化疗不良反应同时减少肺部感染的发生率。

OBJECTIVE To explore the clinical efficacy of Tingli Dazao Xiefei Tang and Daotan Tang combined with chemotherapy in treatment of phlegm-stasis blocking lung cancer and in control of infections.METHODS A total of114patients with advanced lung cancer who were hospitalized for treatment from Jan 2007to Jan 2010were recruited in the study and randomly divided into the observation group with 64cases and the control group with 50cases,both groups received the same chemotherapy program,the observation group was treated with additional Chinese medicine on the basis of chemotherapy,the efficacy,immune function,and incidence of pulmonary infections were observed and compared between the two groups.RESULTS As compared with the short-term efficacy,the total effective rate was 54.0%in the control group,79.7%in the observation group,and there was significant difference（P〈0.05）.The survival rate was 92.2%in the observation group after the treatment for one year,76.0%in the control group;the survival rate was 69.9%in the observation group after the treatment for three years,34.0%in the control group,and the differences between the two groups were significant（P〈0.05）.There was significant difference in immune function levels of the observation group between before and after the chemotherapy（P〈0.05）.The incidence of adverse reactions was 50.0%in the observation group,significantly lower than 80.0%in the control group（P〈0.05）;the incidence of pulmonary infections was 46.9%in the observation group,significantly lower than 74.0%in the control group（P〈0.05）.CONCLUSION Tingli Dazao Xiefei Tang and Daotan Tang can significantly improve the effect of chemotherapy on the patients with phlegm-stasis blocking lung cancer,raise the survival rate,enhance the immune function of the patients,and reduce the incidence of chemotherapy-induced adverse reactions as well as the incidence of pulmonary infections.