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^(99m)Tc-TBI、CPI及MIBI的实验及临床研究进展 被引量：1

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摘要 心肌灌注显像剂的研制对核心脏病学的发展具有重要作用.本文介绍了三种异腈类显像剂的实验及临床研究进展,三者结构的不同决定了其生物学特性的差异.在培养心肌细胞、整体动物及人体的研究表明,TBI肺浓聚早且量多,心肌浓聚少,不适合临床应用;CPI心肌浓聚较多,但肺浓聚仍高,且不能制成稳定药盒,也不适合临床应用;MIBI具有较多的心肌浓聚且肺浓聚少清除快,其理化及生物学特性优良,有较大的临床应用价值.
作者 李胜亭 孝延龄 蒋茂松
机构地区 山东潍坊医学院核医学室 白求恩医科大学附三院 上海华东医院
出处 《国外医学（放射医学核医学分册）》 北大核心 1991年第6期265-269,共5页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 心肌 灌注 显像剂 心脏病
分类号 R541.08 [医药卫生—心血管疾病]
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参考文献3

  • 1M. N. Maisey,A. Lowry,A. Bischof-Delaloye,R. Fridrich,E. Inglese,M. N. Khalil,J. B. Schoot. European multi-centre comparison of thallium 201 and technetium 99m methoxyisobutylisonitrile in ischaemic heart disease[J] 1990,European Journal of Nuclear Medicine(12):869～872
  • 2Annarita Savi,Paolo Gerundini,Paolo Zoli,Lorenzo Maffioli,Antonia Compierchio,Fabio Colombo,Mario Matarrese,Edward Deutsch. Biodistribution of Tc-99m methoxy-isobutyl-isonitrile (MIBI) in humans[J] 1989,European Journal of Nuclear Medicine(9):597～600
  • 3S. T. Benjamin Sia,B. Leonard Holman,Kenneth McKusick,Pierre Rigo,Fredric Gillis,Victor Sporn,Nestor Perez-Balino,Aldo Mitta,Henning Vosberg,Zsolt Szabo,Bodo Schwartzkopff,Jean-Luc Moretti,Alan Davison,John Lister-James,Alun Jones. The utilization of Tc-99m-TBI as a myocardial perfusion agent in exercise studies: Comparison with Tl-201 thallous chloride and examination of its biodistribution in humans[J] 1986,European Journal of Nuclear Medicine(7):333～336

同被引文献16

  • 1楚进锋,李彬,孔德靖,王学斌,张俊波,王金城,米宏志,赵建冬.[^(99)mTcN(PNP5)(NOEt)]^+新型心肌灌注显像剂研究[J].高等学校化学学报,2005,26(6):1014-1017. 被引量：7
  • 2楚进锋,李彬,孔德靖,王学斌,张俊波.新型^(99m)TcN核混配配合物的制备和小鼠生物分布[J].北京师范大学学报（自然科学版）,2006,42(5):514-517. 被引量：3
  • 3O'Rourke R A, Brundage B H, Froelicher V F, et al. American college of cardiology/american heart association expert consensus document on electron- beam computed tomography for the diagnosis and prognosis of coronary artery disease[J]. Circulation, 2000,102:126.
  • 4Germano G, Cama T, Kiat H, et al. A quantitative phantom analysis of artifacts due to hepatic activity in technetium-99m myocardial perfusion SPECT studies [J]. J Nucl Med, 1994, 35:356.
  • 5Boschi A, Uccelli L, Bolzati C, et al. Synthesis and biologic evaluation of monocationic asymmetric ^99mTc- nitride heterocomplexes showing high heart uptake and improved imaging properties [J]. J Nucl Med, 2003,44:806.
  • 6Duatti A, Bolzati C, Uccelli L, et al. Radiopharmaceutical for diagnostic imaging containing a technetium-99m nitride heterocomplex[P]. International Patent: WO 02/09771 Al, 2002.
  • 7Hatada K, Ruiz M, Riou L M, et al. Organ biodistribution and myocardial uptake, washout, and redistribution kinetics of Tc-99m N-DBODC5 when injected during vasodilator stress in canine models of coronary stenose[J]. J Nucl Cardiol, 2006, 13:779.
  • 8Liu S, He Z, Hsieh W,et al. Evaluation of novel cationic ^99mTc-nitrido complexes as radiopharmaceuticals for heart imaging: improving liver clearance with crown ether groups [J]. Nucl Med &Biology, 2006,3:419.
  • 9Leo A J. Calculating lgPooct from structures[J]. Chem Rev, 1993,93:1281.
  • 10Ghose A K, Pritchett A, Crippen G M, Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships III: modeling hydrophobic interactions[J]. J Comp Chem, 1988, 9:80.

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国外医学（放射医学核医学分册）
1991年 第6期

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