路易士酸催化下呋喃锂对L—苏醛的立体选择性加成

STEREOSELECTIVE ADDITION OF FURANYL LITHIUM TO(eR 3R)-1-t-BUTYLDIPHENYL-2 ,3-0-1SOPROPYUOENE L-THRElTAL UNOER LEWIS ACID CATALYSIS

呋喃负离子对(2R,3R)-1-叔丁基二苯硅烷基—2,3—0—异亚丙基—L—苏醛加成的立体化学控制反应中,发现路易士酸溴化锌以适当比例分两步加入,可得到最佳的立体异构比率,顺:反=36:1及较好的顺式产物收率86%.

Stereochemieal control of addition of furanyl anion to L-threital affords excellent isomers rate syn, anti =36:1 with zinc brcmide was used proportion distributing to the reaction of two stept. The tyn-product yield is 86%.