摘要
本工作选用标仪，成年雄性ｗｉｓｔａｒ大鼠。以放射免疫测定法（ＲＩＡ），研究了大鼠由平原（海拔５ｍ，上海）引入高原环境（海拔３４６０ｍ）后，在２４小时内急性习服期，垂体及各脑区β－内啡肽样免疫活性物质（βｐ－ＥＰＬＩ）的含量变化。结果表明：大鼠在高原２４小时急性习服期，高原实验组与平原对照组相比，垂体内β－ＥＰ含量降低非常显著（Ｐ＜０．０１）。纹状体、下丘脑、丘脑、桥延、海马，中脑内β－ＥＰ含量增加非常显著（Ｐ＜０．０１）。据此证实，急性高原低氧环境能影响垂体β－ＥＰ的分泌与释放。提示，脑内β－ＥＰＬＩ参与高原低氧的应激反应过程。可能作为神经递质和调质，通过神经－内分泌环路在应激反应中起介导作用，β－ＥＰ可能为中枢神经系统内调节应激反应的主要应激激素之一。
he effect of hypoxia on β-EP content in the brain of rats
which were acutely taken intoTianjun(Qinghai,3 560m.) was studied
with radioimmunoassay.The results showed that the con-tents ofβ-EP
in hypophysis were deceased(P<0.01),the contents in copus
striatum,hypothala-mus,thalamus,pons-oblongats,hippocampus,mesencepha
lon were increased(P<0.01),and thecontents in contex were not
significantly changed(P>0.05),as compared with controls.It
wassuggested that theβ-EP in brain may play a role in the adaptation
to acute hypoxia.
出处
《高原医学杂志》
CAS
1995年第1期44-47,共4页
Journal of High Altitude Medicine
基金
省卫生厅资助
