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替硝唑的非等温热分解动力学及热稳定性研究 被引量:3

Thermal Decomposition Kinetics of Tinidazole and Its Stability Study
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摘要 报道了用热重法 ( TG)研究替硝唑 ( Tinidazole,TNZ)原药及片剂中替硝唑热分解非等温动力学以及药物的稳定性 ,并对用热重分析仪测定片剂含量的方法进行了探讨 .推断出原药热分解过程为零级反应 ,其动力学方程为 :dα/ dt=Ae-EaRT,热分解反应活化能 Ea为 99.7k Jmol-1,指前因子 A为 3.60× 10 7s-1;片剂中替硝唑的热分解过程为三维扩散级反应 ,其动力学方程为 :dα/ dt=Ae-EaRT3 / 2 ( 1+α) 2 / 3 / [( 1+α) 1/ 3 - 1],活化能 Ea为 10 5.1k Jmol-1,指前因子 A为 1.0 8× 10 6s-1.实验表明 :替硝唑原药具有较高的热解活化能 ,热稳定性较好 ;在片剂中热分解机理和分解活化能发生改变 ,说明赋形剂对药物的热稳定性有一定影响 .根据得到的热分解反应的机理函数和动力学参数 ,得到片剂有效存贮期与贮存温度的关系曲线 ,估算出在室温 ( 2 5℃ )下 ,分解率为 10%时药物的存贮期为 2 6.7年 ,分解率为 5%时所需要的时间约为 6. This paper reported the study on the non\|isothermal decomposition kinetics and stabilities of tinidazole and its tablet by thermogravimetry technique.The thermal decomposition process of pure tinidazole was subjected to zero order reaction, which activation energy and preexpontial factor were 94.7 kJ mol\+ -1 and 3.60×10\+7 s\+ -1 , respectively. The thermal decomposition process of tinidazole in tablet was subjected to Anti\|Jander mechanism, which activation energy and preexpontial factor were 105.1 kJ mol\+ -1 and 3.20×10\+6 s\+ -1 respectively. It showed that tinidazole in free situation had high decomposition activation energy and was stable. The variation of mechanism and decomposition activation energy in tablet showed that excipients had some affection on the process of pure pharmaceutical. The curves of shelf temperature and time were drawn.with decomposition kinetic function model and kinetic parameters. The shelf time was about 26.7 years at room temperature(25℃) according to the curve.
出处 《中南民族学院学报(自然科学版)》 CAS 2001年第1期83-87,共5页 Journal of South-Central University for Nationalities(Natural Sciences)
关键词 替硝唑 热重法 非等温动力学 热稳定性 有效存贮期 热分解 药物 热解活化能 tinidazole thermogravimetry (TG) non\|isothermal decomposition kinetics thermal stability shelf\|time
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