单核巨噬细胞在急性胆道感染所致肺损害中的作用

The role of mononuclear phagocyte system in the pathogenesis of lung injury during acute obstructive cholangitis

本实验选用健康Wistar大鼠90只,通过复制急性胆道感染动物模型,观察单核巨噬细胞系统(MPS)功能变化在胆道感染所致肺损伤中的作用。结果发现,随着肝枯否细胞吞噬功能抑制,肺内MPS代偿性激活并产生大量氧自由基等炎性介质导致急性肺损伤。提示:急性胆道感染所致肺损害与宿主防御系统,特别是MPS功能状态密切相关,MPS功能紊乱可能在胆道感染所致肺损害中起重要作用。

The relationship between the behavior of the mononuclear phagocyte system(MPS)and acute pulmonary injury during acute obstructive cholangitis(AOC)was investigated in 90 Wistar rats.After the operation to induce actue obstructive cholangitis,the animals were killed in the Oth,6th,12th,24th and 48th hour,and the phagocytic function of Kupffer's cells,the number of alveolar macrophages in the lung lavage fluid,and the extravascular water content of the lungs were measured.And the pulmonary levels of lipid peroxidase and supperoxide dismutase were determined as well.It was found that when the phagocytic function of Kupffer's cells was suppressed,the alveolar macrophages were activated by the invading bacteria to release some inflammatory mediators such as free radicals resulting in acute pulmonary injury.It seems that there is a close relationship between the fuctional status of mononuclear phagocyte system and the development of pulmonary injury,and the functional failure of mononuclear phagocyte system plays an important role in the pathogenesis of multiple organ failure especially of acute pulmonary injury.