高海拔地区低氧环境对新战士血管内皮细胞损害的研究

Injuries of Vascular Endothelial Cells Due to Hypoxia Environment Among Young Soldiers Rapidly Entering Plateau.

目的 探讨青年战士急进高海拔地区不同高度 ,不同居住时间低氧环境下对血管内皮细胞 (VEC)的损害。方法 对从平原进驻海拔 3 5 0 0 m和 45 0 0 m地区的第 7天和半年的 180名新兵进行循环内皮细胞 (CEC) ,内皮素 (ET) ,6 -酮 -前列腺素 Fia(6 - kto- PGFia)和血栓素 B2 (TXB2 )等测定 ,并与 80名平原健康新兵作对照。结果 海拔 3 5 0 0 m第 7天组较平原组 CEC,ET,TXB2 有不同程度升高 (P<0 .0 5～ 0 .0 1) ,居住半年后上述指标较平原组无显著改变 ,海拔45 0 0 m第 7天组较平原组 CEC,ET,TXB2 均有显著升高 (P<0 .0 1) ,半年后上述指标较平原组无明显改变。 6 - kto-PGFia两组第 7天 ,半年均无显著差异。结论 高海拔地区低氧对 VEC的损害主要在早期 ,海拔愈高损害愈明显 ,预防进驻高海拔地区心血管疾病关键在早期。

Objective To understand the injuries of vascular endothelial cells (VEC) due to hypoxia environment among young soldiers rapidly entering plateau with different altitudes and residential durations Methods The contents of circulatory endothelial cells (CEC),endothelin (ET),6 keto prostaglandin Fia (6 kto PGFia) and thromboxane B 2 (TXB 2) in peripheral blood of 180 new soldiers came from plain were determined at 7th day and 6th month after their rapid entering plateau with the altitude of 3 500 meter and 4 500 meter,and were compared with those of 80 healthy new soldiers stationed in the plain Results The levels of CEC,ET and TXB 2 revealed significant increases with different degrees among new soldiers at the 7th day after their entering plateau with the altitude of 3 500 meter ( P<0 01~0 05 ) and 4 500 meter ( P<0 01 ),and no significant variations at the 6th month compared with those of controls No significant variations were observed in levels of 6 kto PGFia in peripheral blood of new young soldiers at the 7th day and the 6th month after their entering plateau with the altitudes of 3 500 and 4 500 meter Conclusion The injuries of VEC due to hypoxia environment mainly occured during the early stage of entering plateau,and deteriorated gradually with the increase of altitudes So the prevention of cardio vascular diseases of soldiers entering plateau with high altitudes should be done at the early stage