血清可溶性白细胞介素2受体测定在病毒性肝炎中的意义

THE SIGNIFICANCE OF SOLUBLE INTERLEUKIN-2 RECEPTOR IN PATIENTS WITH VIRAL HEPATITIS

为探讨急慢性病毒性肝炎血清可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）的改变，及其在诊断、病情演变和预后判定中的意义。本文作者采用夹心酶联免疫吸附法测定１０１例急慢性病毒性肝炎血清ｓＩＬ－２Ｒ水平（包括急性病毒性肝炎８０例、慢性乙型肝炎２１例），急性和慢性病毒性肝炎患者血清ｓＩＬ－２Ｒ分别为９０７．９±２５４．０ｕ／ｍｌ和７９５．７±１９８．２ｕ／ｍｌ，均明显高于对照组（Ｐ＜０．０１），急性肝炎组明显高于慢性肝炎组（Ｐ＜０．０１）；其中急性病毒性肝炎黄疸期血清ｓＩＬ－２Ｒ明显高于恢复期（Ｐ＜０．０１），各型急性病毒性肝炎之间血清ｓＩＬ－２Ｒ差异无显著性（Ｐ＞０．０５）。结果提示：急性和慢性病毒性肝炎患者血清ｓＩＬ－２Ｒ水平均明显增高，其水平的高低在一定程度上反映了机体免疫功能状态、肝细胞损伤及炎症程度。

o study the alteration of serum soluble interleukin-2 receptor in patients withacute and chronic viral hepatitis,and to look for a reliable basis of diagnosis,evolu-tion of illness and judgemet of prognosis.The levelof soluble interleukin-2 receptors(sIL-2R) were measured by an enzyme linked immunosorbent assay in l0l cases ofacute and cbronic viral hepatitis,including 80 cases of acute hepatitis and 2l cases ofchronic hepatitis B.The serum sIL-2R levels in the cases of acute viral hepatitis andchronic hepatitis B were 907.9 ± 254.0u/ml and 795.7 ± 198. 2u/ml respectively, whichwere higher than that of normal control(n=30)(P<0.01),the sIL-2R levels in ictericstage of acute viral hepatitis were higher than that of chronic hepatitis(P<0.01). Thelevels in icteric stage of acute viral hepatitis were significantly higher than that ofrecovery stage(P<0. 01). No significant difference was found among hepatitis type A,B,C, D and E(P>0. 05). The serum sIL-2R levels in patients with acute and chronicviral hepatitis are increasesd obviously,reflecting the patients’immune function,degreeof liver cells damage and inflammation.