立体定向^(32)P内放疗后脑瘤的临床病理研究

Pathology of brain tumors after stereotactic injection of radionuclide of ^(32)p

本文通过光镜观查15例肿瘤接受^(32)P治疗后的病理结果,重点分析了^(32)P对几种常见脑瘤细胞的杀伤力和对肿瘤周围正常脑组织的影响发现:(1)^(32)P是一种作用较温和的内放疗治疗肿瘤的药物。对星形细胞瘤和间脑部位体积较小的肿瘤抑制作用较强,而对质地坚韧的脑膜瘤和含丰富胶元纤维及血管的肿瘤破坏作用较差。(2)内放疗可引起较局限性的肿瘤周围正常组织的改变,此病理改变与放疗药物的剂量有关。本文为临床治疗肿瘤,选择效疗药物的种类、剂量提供了客观的依据。

Stereotactic injection of radionuclide is a newmethod in treatment of brain tumors presentlyUntill now there are no report of pathologicexamination of brain tumors after internal irra-diation was. red in China. The specimens ofbrain tumors after stereotactic injection ofradionuclide of ^(32)P were studied by light mi-croscope in 15 patients. The damage abilityfro tumor cells and normal tissure around tumorwere investigated. The results of pathologicalchanges showed: (1)^(32)p were moderate damageto brain tumor. It was mere effective on astro-cytoma and smaller diencephalon tumor andtess effected on meningioma or tumors withabundant collagen fibers. (2) confine damagesof normal tissures around tumor were spongiformcdema of white matter. small hemorrhage.inflammatory cells around vessels and gliosisthe pathological change responded to the dosageof injection of radionuclides was considered.Mechanism of above pathological changes arediscusses.