双苯氟嗪对小鼠记忆障碍的改善作用(英文)

Improving effect of dipfluzine on amnesia in mice

用跳台法和电迷宫法,观察双苯氟嗪(dipfluzine)对亚硝酸钠和戊巴比妥钠造成的小鼠记忆障碍的改善作用,双苯氟嗪可明显改善亚硝酸钠引起的小鼠记忆障碍和戊巴比妥钠造成的小鼠方向辨别的获得障碍,且有剂量关系,20和40mg·kg^(-1)双苯氟嗪使小鼠跳台错误次数和出现跳台错误动物的百分率均显著低于溶剂对照组.20 mg·kg^(-1)双苯氟嗪使小鼠在训练的d1和d2受到电刺激后的正确逃避反应数均显著高于溶剂对照组(P<0.05).双苯氟嗪改善亚硝酸钠引起的小鼠记忆障碍的作用与桂利嗪(cinnarizine)相似,在改善记忆的有效剂量(20mg·kg^(-1))下,双苯氟嗪还有抗小鼠急性脑缺氧作用,使断头后小鼠张口呼吸动作持续时间(32±s7s)显著长于溶剂对照组(20±s4s,P<0.01).

Dipfluzine {1-diphenyl methyl-4-[4-(p-fluorophenyl)-4-oxobutyl]-piperazine, Dip} is a new derivative of cinnarizine (Cin). The improving effects of Dip on the amnesia induced by sodium nitrite and sodium pentobarbital in mice were studied using a step-down test and an electric maze method respectively. Dip improved sodium nitrite-induced impairment of the retention of memory in the step-down test, which was similar to Cin, and improved sodium pentobarbital-induced impairment of the orientation in the electric maze test in mice significantly. In the doses of 20 and 40 mg·kg-1, both Dip and Cin significantly decreased the error times of mice and the percentage of the animals showing errors (P<0.05 and P<0.01 respectively, compared with the solvent control) in the step-down test, but 10 mg·kg-1 of both drugs did not. In the electric maze test 20 mg ·kg-1 of Dip increased the times of the correct response of mice significantly in d 1 and d 2 of training (P<0.05, compared with the solvent control), but 10 mg·kg-1 of Dip did not. At the effective dose (20 mg·kg-1) of influencing memory, Dip made the duration (32.2± s 6.6 s) of breathing movement with the mouth opened after the decapitation longer than that of the solvent control (20.2± s 3.8 s) significantly (P<0.01), and thus protected mice against the acute cerebral hypoxia.