三氧化二砷、黄磷、四氯化碳的急性肝脏毒作用的研究

Comparative Studies on Acute Hepatotoxicity of Arsenic Trioxide,Phosphorus and Carbon Tetrachloride

大鼠每日分别经口染毒三氧化二砷(45mg/kg)、黄磷(3mg/kg)、四氯化碳(990mg/kg),连续4日后,均出现肝脏病理改变。黄磷及四氯化碳组大鼠的血清GPT和GOT活性明显升高,但二氧化二砷组则无显著变化。三个染毒组大鼠的血清和肝微粒体过氧化脂质含量、血清IgM和补体C_3含量均较对照组显著升高。

After beieg exposed respectively to As2O3 ( 45mg/kg/day ) P ( 3mg/kg/day ) and CCl4 ( 990mg/ kg/day ) by oral administration for four days, all three groups of Wistar rate showed remarka ble liver pathological changes. P and CCl4 groups had higher levels of SGPT and SGOT activi ties than that of the control, but As2O3 group had not similiar phenomenon, it may not be suit able that SGPT and SGOT act as sensitive indices to evaluate the acute hepatotoxicity of arse nic. The concentration of lipid peroxidants of serum and microsomes and ssrum IgM and O3 were significantly elevated, lipid peroxidation and allergic action may play some roles in the hepa toxicity of these three chemicals.