女性因素与脑卒中

RELATIONSHIP BETWEEN FEMALE FACTORS AND STROKE

本文采用条件Ｌｏｇｉｓｔｉｃ回归分析的方法，对１２８例女性脑卒中病人及其健康对照，进行了１：１配对的对比研究，计算其ＯＲ值。单因素结果表明：月经初潮年龄、妊娠次数与女性脑卒中呈明显的正相关（ＯＲ＝１．３０和１．１７，ｐ＜０．００２和Ｐ＜０．０５），而绝经年龄、生产次数、自然流产次数以及生殖周期则和女性脑卒中呈明显的负相关（ＯＲ＝０．９６、０．４５和０．４５．Ｐ分别＜０．０２、＜０．０１、＜０．０１和＜０．００１）；但经高血压病史和吸烟调整以后，则月经初潮年龄晚、绝经年龄早及生殖周期短是女性脑卒中独立的危险因素，ＯＲ值分别为１．３５和１．３３、０．９６和０．９６、０．９２和０．９２。说明初潮年龄早、绝经年龄晚以及生殖周期长是女性脑卒中独立的保护因素。本研究未发现女性激素与女性脑卒中的相关关系。

case-control study was conducted in 128 femalestroke and their matched controls ,and a conditional logisticmodel was used to calculate their odds ration (OD),Theresults of single factor showed that menarche age and thenumber of pregnancy had outstanding correlation withstroke in women(OR=1.30and1.17;P<0.002 and P<0. 05 respectively).But menopause age,the number of pro-duction, the number of natural abortion, and reproductiveperiod had negative relationship with female stroke(OR=0.96,0.45,and0.45:P<0.02,<0.01,and<0.001 re-spectively).After adjusted by hypertension and smoking,older menarche age,younger menopause age and long re-productive perior were independent risk factors for the fe-male strode,OR were 1.35 and 1.33,0.96 and 0.96,0.92and0.92 respectively. These results showed that youngermenarche age,older menopause age,and longer reproduc-tive period were independent risk factros of femaale stroke.The relationship of female hormone and stroke was notfound in this stud