细胞外信号调节蛋白激酶在前列腺上皮内瘤组织中的表达及意义

Expression of extracellular signal-regulated kinase in intraepithelial neoplasi

目的 探讨细胞外信号调节蛋白激酶 (ERK)在前列腺上皮内瘤 (PIN)组织中表达的意义。 方法 应用免疫组织化学SP法检测 12例PIN、11例前列腺癌 (PCa)及 16例BPH组织标本中ERK的表达。 结果 12例PIN标本均有表达 ,其中 6例为高表达 ;11例PCa组织 10例为阳性 ,但多为弱表达 ;16例BPH组织 12例为阳性 ,表达也较弱。PIN组织中ERK表达与PCa组和BPH组比较差异有显著性意义 (P <0 .0 5 ) ,PCa组与BPH组相比差异无显著性意义 (P >0 .0 5 )。 结论 ERK在PIN组织中呈高表达 。

Objective To study expression of extracellular signal-regualated kinase in intraepithelial neoplasia,prostatic cancer and BPH tissue. Methods Expression of extracellular signal-regualated kinase (ERK) was determined in 12 prostatic intraepithelial neoplasia (PIN),11 prostate cancer and 16 benign prostatic hyperplasia specimens.ERK expression was determined by immunohistochemistry. Results ERK expression was positive in all the 12 PIN specimens,6 of which being overexpressed.In the 11 prostate cancer specimens,overexpression was observed in only one while the other 10 under expressed.Overexpreassion was not observed in all the BPH specimens whereas 12 of the 16 showed underexpression. Conclusions ERK expression is obviously higher in PIN tissue (P<0.05) and might play a role in PIN tumorigenesis.