MR灌注成像在肺栓塞诊断中的应用

MR pulmonary perfusion in the diagnosis of experimental pulmonary embolism

目的 探讨MR二维快速扰相梯度回波序列 (2DFSPGR)显示肺实质灌注的可能性 ,以及在实验性肺栓塞中的应用价值。方法 11只在体犬肺栓塞模型在平静呼吸下行肺MR灌注扫描 ,定性及定量评价图像质量 ,与病理解剖对照分析肺灌注扫描诊断肺栓塞的敏感性。结果 10只犬的MR图像质量为优良 ,可显示肺实质灌注情况 ,平均信号 /噪声比 (SNR)为 6 7 4± 18 0 ,对比度 /噪声比(CNR)为 40 9± 14 2。正常灌注区的信号强度平均值为 39 7± 5 1,灌注不良区域信号强度平均值为15 6± 2 1,灌注不良区域时间 强度曲线表现为峰值下降或曲线平直。结论 MR肺灌注成像是诊断肺栓塞的可行方法。

Objective To probe into the feasibility of MR pulmonary perfusion (MRPP) and its value in diagnosis of acute pulmonary embolism (APE). Methods Eleven dogs with APE induced by autologous blood clots were examined using two-dimensional fast spoiled gradient echo sequence (2D FSPGR) without breath-hold. Images were assessed qualitatively and quantitatively. MR findings were compared with those of pathologic dissections. Results 10 sets of images were excellent or good. SNR was 67.4±18.0, CNR was 40.9±14.2. The average value of signal intensity was 39.7±5.1 in the district of normal perfusion,15.6±2.1 in the area of perfusion defect. Time-intensity curve of perfusion defect manifested as decreased peak intensity or flat curve.Conclusion MRPP with 2D FSPGR without breath-hold is a feasible method to diagnose APE.