纤维环切开诱导兔非机械性神经根损伤

Incisure of analus fibrosus to induce nonmechanical injury of nerve root in rabbits

目的 观察自体髓核组织对神经根的影响。 方法 成年家兔 30只 ,随机分成实验组和对照组 ,每组又分为术后 1,3,7d组 ,各 5只。实验组在兔L6 ,7间盘纤维环上钻孔 ,使髓核组织通过渗漏与邻近神经根相接触 ;对照组保持纤维环完整。术后 1,3,7d ,以电生理方法观察各组神经根传导功能的动态变化 ,同时观察神经根的组织学及超微结构。 结果 术后 1,3 ,7d ,实验组神经根传导速度逐渐下降 ,分别为 (6 0 .12± 0 .71)m s、(4 9.6 3± 1.0 7)m s、(30 .76± 1.36 )m s ;神经纤维发生轻微病理改变。术后 3d ,电镜下可见雪旺细胞肿胀 ;术后 7d ,还可见部分神经纤维的施兰切迹增大。 结论 单纯将纤维环切开 ,髓核组织通过渗漏可使邻近神经根结构与功能发生改变 。

Objective To observe the effect of autollogous nucleus pulposus on the nerve root. Methods In the experimental group a hole was drilled on fibrous analus of lumbar 6 7 intervertebral disk, in order that the nucleus pulposus was contacted with adjacent nerve root by leaking. In the control group, fibrous anulus was intact. At days 1,3,and 7 postoperatively, dynamic changes of conduction function of each nerve root, histology and ultrastructure of the nerve root were observed with electron physiological method. Results In the experimental group, the conducting velocity of the nerve root decreased gradually: (60.12 ± 0.71) m/s , (49.63 ± 1.07) m/s, and (30.76 ± 1.36) m/s, respectively, and mild pathological changes could be seen in nerve fibres. At the 3rd day Schwann cell swelling could be observed under electron microscope and at 7th day Schmidt Lanterman incisure of some nerve fibres enlarged. Conclusions After the fibre anulus is incised, the pulpous nucleus in it can induce structural and functional changes of nerve root by leaking, leading to nonmechanical injury to the nerve root.