肝硬化患者血浆降钙素基因相关肽水平的检测及其临床意义——附58例报告

The clinical significance of determining plasma calcitonin gene-related peptide level in patients with hepatic cirrhosis:a report of 58cases.

目的:探讨肝硬化患者的血浆降钙素基因相关肽(CGRP)水平的变化及其临床意义。方法:应用放射免疫分析法测定58例肝硬化患者(其中有腹水42例)和20名健康人的血浆CGRP水平并作对照。结果:肝硬化组血浆CGRP(57±23)ng/L显著高于对照组25±8)ng/L,<0.01;肝硬化组中有腹水者的血浆CGRP水平79±20)ng/L明显高于无腹水患者48±14)ng/L,<0.01;按肝功能ChildPugh分级,其C级的血浆CGRP水平高于B级,B级高于A级。线性相关分析显示,肝硬化患者的血浆CGRP水平与胆红素、凝血酶原时间无显著性相关,与白蛋白水平呈显著性负相关。结论:肝硬化患者血浆CGRP水平增高,其增高可能与肝功能损害和血流动力学紊乱有关。

Objective:To study the level of plasma calcitonin gene-related peptide(CGRP)and to assess its clinical signifi-cance.Methods:The plasma levels of CGRP were measured in58patients with hepatic cirrhosis (42cases with ascites)and in20normal controls by radioimmunoassay (RIA).Results:Plasma CGRP levels were significantly higher in patients with cirrhosis than in controls(57±23ng /L vs25±8ng /L,P<0.01).The levels of plasma CGRP were markedly higher in cirrhotic patients with ascites than those without (79±20ng /L vs48±14ng /L,P<0.05).According to the Child-Pugh classification,the level of plasma CGRP significant-ly increased with the severity of liver cirrhosis.There was no correlation between plasma CGRP and bilirubin as well as prothrombin time,but the levels of CGRP correlated negatively with the level of plasma albumin.Conclusion:The increased levels of plasma CGRP are probably associated with the severity of liver cirrhosis and the haemodynamic derangement?