急性一氧化碳中毒患者血清甲状腺素测定及临床意义

Changes and clinical significance of thyroid hormones in patients with acute carbon monoxide poisoning

目的 :探讨急性一氧化碳中毒时血清甲状腺激素的变化及意义。方法 :以 2 5例急性一氧化碳中毒患者和 2 0例健康成年人为研究对象 ,采用放射免疫分析法测定甲状腺激素。结果 :①中毒组T3 、FT3 明显低于对照组 ,且中毒越重下降越明显 (P <0 .0 1) ;②各组间T4 、TSH无显著性差异 (P >0 .0 5 ) ;③中毒组FT4 低于对照组 (P <0 .0 1)。结论 :急性一氧化碳中毒时甲状腺激素明显下降 ,且与病情严重性有关 ,可作为中毒程度的一个监测指标。

Objective:To investigate the changes and significance of thyroid hormones in acute carbon monoxide poisoning patients.[WT5HZ]Methods:25 patients with acute carbon monoxide poisoning and 20 healthy subjects were chosen for determining thyroid hormone with radioimmunoassay.Results:①T 3 and FT 3 in patient's group were significantly lower than those in control group( P <0.01),and correlated with the severity of poisoning;②T 4,TSH shown no difference between two groups( P <0.05);③The FT 4 in patients was much lower than that in control guoup( P <0.01).Conclusion:Thyroid hormones T 3,FT 3,FT 4 decreased markedly in patients with acute carbon monoxide poisoning and they can be regarded as marks for severity of carbon monoxide poisoning.