上皮型钙粘连素和CD44v6在人肝细胞癌中的表达

E-cadherin and CD44v6 expression in human hepatocellular carcinoma

目的 :探讨粘附分子上皮型钙粘连素 (E- cadherin)和 CD44 v6在人肝细胞癌 (HCC)中表达的意义。 方法 :用免疫组化法检测 6 6例人 HCC组织中 E- cadherin和 CD44 v6的表达。 结果 :人 HCC中 E- cadherin和 CD44 v6表达的阳性率分别为42 .4%和 39.4% ,且 E- cadherin表达与 HCC侵袭转移倾向呈负相关 (P<0 .0 1) ,与患者 5年生存率呈正相关 (P<0 .0 1) ;而CD44 v6表达与 HCC侵袭转移倾向呈正相关 (P <0 .0 1) ,与患者 5年生存率呈负相关 (P <0 .0 5 )。 结论 :E- cadherin和CD44 v6均与肝癌侵袭转移倾向有关 ,检测 E- cadherin和 CD44 v6的表达可以作为判断肝癌预后的参考指标。

Objective: To investigate the significance of E cadherin and CD44v6 expression in human hepatocellular carcinoma(HCC). Methods: Immunohistochemical method was used to detect E cadherin and CD44v6 expression in 66 cases of HCC. Results: The positive rates of E cadherin and CD44v6 expression in human HCC were 42.4%(28/66)and 39.4% (26/66) , respectively. There was a negative correlation between E cadherin expression and invasive, metastatic potential of HCC ( P < 0.01) and a positive correlation between the CD44v6 expression and invasive, metastatic potential of HCC ( P < 0.01). Moreover, the survival of patients for 5 years in E cadherin positive expression group was higher than that in E cadherin negative expression group( P <0.01), and the survival of patients for 5 years in CD44v6 positive expression group was lower than that in CD44v6 negative expression group( P <0.05). Conclusion: These data show a correlation between E cadherin and CD44v6 expression and invasive and metastatic potential in HCC. E cadherin and CD44v6 expression may be 2 prognostic indicators in HCC. [