摘要
了解腹膜透析患者的骨代谢状况。用IRMA、RRA和RIA对 2 4例持续不卧床腹膜透析 (CAPD)患者测定血清PTH(1- 84)、2 5 (OH)D3 、1,2 5 (OH) 2 D3 、BGP以及血Ca和P的变化。结果表明 :尿毒症患者PTH和BGP升高 ,CAPD可以使其降低 ;2 5 (OH)D3 和 1,2 5 (OH) 2 D3 降低 ,CAPD对其无明显影响 ;PTH与 2 5 (OH)D3 、1,2 5 (OH) 2 D3 呈负相关 ,P分别小于 0 .0 5和 0 .0 1;PTH与BGP呈正相关 (P <0 .0 1) ,CAPD可使其相关性降低。提示PTH分泌亢进是骨代谢紊乱的主要因素之一 。
Bone metabolism in patients with chronic renal failure treated by continuous ambulatory peritoneal dialysis(CAPD) was evaluated. IRMA, RRA and RIA were used to detect PTH, 25(OH)D 3,1,25(OH) 2D 3,BGP,Ca and P levels in the blood of 24 CAPD patients. PTH and BGP were increased in uremic patients and decreased after CAPD. 25(OH)D 3 and 1,25(OH) 2D 3 were decreased in the patients, but their levels were not changed further after CAPD. PTH had negative correlation with 25(OH)D 3( r =-0.379, P < 0.05 ) and 1,25 (OH) 2D 3 ( r =-0.451, P <0.01).PTH had positive correlation with BGP ( r =0.501, P <0.01)in CAPD patients, and the correlativity was decreased by CAPD. The results showed: PTH hypersecretion is a main factor inducing bone metabolism disturbance, and bone turnover rate is decreased in these patients by CAPD.
出处
《标记免疫分析与临床》
CAS
2001年第1期15-17,共3页
Labeled Immunoassays and Clinical Medicine
