急性髓性白血病患者血清胆固醇水平变化与低密度脂蛋白受体活性的关系研究

Relationship between serum cholesterol and low dense lipoprotein receptor activity of patients with acute myelogenous leukemia

测定了 5 2例初发未治急性髓性白血病 (AML)患者血清胆固醇浓度及其外周血白血病细胞对 1 2 5 I-低密度脂蛋白 (1 2 5 I- L DL )的降解率 ,结果显示两者呈负相关 ,白细胞数及 1 2 5 I- L DL降解率较高者血清胆固醇浓度较低 ,化疗后 ,随着外周血白血病细胞消失 ,血清胆固醇及 L DL 胆固醇水平升高。据此推测 AML 患者的低胆固醇血症可能归因于白血病细胞的 L DL受体活性增高 ,白血病细胞对 L DL的高摄取及降解为利用 L DL作为化疗药物的载体靶向治疗白血病提供了新思路。

The serum cholesterol concentration and the rates of degradation of 125 I low density lipoprotein( 125 I LDL)by isolated leukemic cells of 52 patients with acute myeloblastic leukemia at diagnosis were assayed The results showed that the lowest serum cholesterol concentrations were found in the patients with very high rates of cellular degradation of 125 I LDL After chemotherapy,both LDL cholesterol and total serum cholesterol levels rosed concomitantly with the fall in white blood cell counts This suggests that a high receptor mediated uptake and degradation of LDL by the leukemic cells may be the cause of hypocholesterolaemia in acute myeloblastic leukemia LDL receptor activity in leukemic cells may provide a basis for therapeutic approaches