哮喘患者花粉皮试和血清总IgE、IL-4表达及激素干预的影响

Expressions of serum Ig E and IL-4of asthma patients with pollen testor inhaled glococorticoid

通过花粉皮试和测定血清总免疫球蛋白 E (Ig E)、血清细胞因子白介素 - 4(IL - 4)水平 ,比较哮喘缓解期、发作期糖皮质激素吸入治疗前后的变化 ,并与正常组进行对照。结果显示 ,哮喘发作期花粉皮试阳性率最高 ,治疗组和正常组阳性率较低 ;血清总 Ig E、IL- 4水平发作期和缓解期与治疗后和正常组比较 ,差异非常显著(P<0 .0 1) ;并且皮试阳性率与 Ig E、IL- 4水平呈正相关 (P<0 .0 1)。认为过敏原皮试和 Ig E、IL- 4水平测定同样可作为诊断哮喘的重要依据 。

In order to observe the treatment effects of asthma patients with inhaled glucocorticoid,the pollen test,the measurements of lg E and L L- 4were carried on.The resultsshowed thatthe pollen skin testhad the highest positive rate atattacking periods,the team and control group had lowerpositive rate.A singnificantdifference of level of Ig E and IL- 4was found compared the results of attacking period and rem ission period with the results after treat- ment and control group (P<0 .0 1) .The positive rate of pollen skin test had positive correlation with the levels of Ig E,IL - 4(P<0 .0 1) .Itsuggested thatallergen skin testand measurem entof Ig E and IL - 4were diagnostic of asth- ma and inhaling glucocorticoid was an importanttreatmentmethod atasthma acute attack period and rem ission peri- od.