ACEI对AMI后患者长期抗缺血及降低缺血事件的作用

Long-term anti-ischemits and reducing the incidence of ischemia-related of angiotensin-co-onverting enzyme inhibition in patients after acute myocardial infarction

目的 观察血管紧张素转换酶抑制剂 (ACEI)减少急性心肌梗塞 (AMI)后患者心肌缺血及其相关事件的影响。方法 将 87例AMI后患者随机分为 43例服用开博通治疗组和 44例常规治疗对照组 ,于出院前、出院后 3个月、6个月和 1年行hoter心肌缺血总负荷检测 (TIB) ,并观察缺血相关事件。结果 于出院后 1年 ,治疗组TIB才显著低于对照组 (P <0 0 5 ) ,并且缺血相关事件明显少于对照组 (P <0 0 5 ) ,但出院后前 6个月两组差异并不明显 ,至出院后 6个月才出现明显的差异。

AIM To study the effect of angiotensin converting inhibitor(ACEI) reduces myocardial ischemia and related events after acute myocardial infarction(AMI). We studied 87 patioents who had been randomly divided into captopril group and conctrol group. All patients underwent total ischemic burden(TIB) testing from 24 ambulatory electgocardiogram recording before and 3,6 and 12 months after hospital discharge,and were observed ischemia related events. RESULTSTIB in the 12 months,significantly fewer ischemia related events occurred in the captopril groups( P< 0 05). This difference was found between 6～12 months but not during first 6 months. CONCLUSION ACEI has long term anti ischemic effect and may reduce the incidence of ischemia related events after AMI.