摘要
目的：探讨Ｌｉｎｏｍｉｄｅ对胃癌生长和转移的作用。方法：将人胃癌细胞株ＳＧＣ７９０１原位种植于裸鼠，制成胃癌模型。在荷瘤鼠饮用水中加入不同剂量的Ｌｉｎｏｍｉｄｅ，于第１０周时处死动物，测定肿瘤体积并检查胃周淋巴结转移情况。结果： Ｌｉｎｏｍｉｄｅ抑制胃癌生长的作用程度与其剂量有关，１６０ ｍｇ／ｋｇ的Ｌｉｎｏｍｉｄｅ对胃癌生长抑制作用明显（Ｐ＜０．０５）；对胃周淋巴结转移的抑制率与对照组比较无显著差异（Ｐ＞０．０５），但抑制率达到４０％。结论：Ｌｉｎｏｍｉｄｅ是胃癌生长和转移的一种有效抑制剂，其抗肿瘤作用及机制值得进一步研究。
Background/Aims: To study the effect of Linomide on growth and lymph node metastasis of gastric cancer. Methods: Nude mice model of gastric cancer was made by implanting SGC7901 cell line in mice stomach. The mice with tumor were given drinking water containing Linomide in different dosages and killed on the 10th week, the tumor volume and metastatic lymph nodes were examined. Results: The inhibitory effect of Linomide on tumor growth was related to its dosage, and was more obvious at the dosage of 160 mg/kg (P< 0.05). At this dosage, Linomide exhibited 40% inhibitory rate on the perigastric regional lymph node metastasis, but there was no significant difference between Linomide group and the controls (P> 0.05). Conclusions: Linomide is an effective inhibitor on growth and metastasis of gastric cancer. It is worthwhile to investigate further on its anticancer effects and the mechanisms of action.
出处
《胃肠病学》
2001年第1期33-34,共2页
Chinese Journal of Gastroenterology
